The Journal of the American Society for Mass Spectrometry has just published our latest article in which we look at zebrafish eyes using imaging mass spectrometry. We analyzed frozen eye cross sections of zebrafish larvae using cryo-ToF-SIMS and we visualized the retinal pigment epithelium with mass peaks that we attribute to leucodopachrome, an intermediate in the biosynthesis of melanin. A first!
Van Nuffel, S.; Ang, K.C.; Lin, A.; Cheng, K. Chemical Imaging of Retinal Pigment Epithelium in Frozen Sections of Zebrafish Larvae using ToF-SIMS. J. Am. Soc. Mass Spectrom. 2020. DOI: 10.1021/jasms.0c00300